Hirudin, a new therapeutic tool?

Author:

Bichler J.,Fritz H.

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference69 articles.

1. Agnelli G, Pascucci C, Cosmi B, Nenci GG (1990) The comparative effects of recombinant hirudin (CGP 39393) and standard heparin on thrombus growth in rabbits. Thromb Haemost 63: 204–207

2. Bichler J, Fichtl B, Siebeck M, Fritz H (1988) Pharmacokinetics and pharmacodynamics of hirudin in man after single subcutaneous and intravenous bolus administration. Drug Res 38: 704–710

3. Bichler J, Siebeck M, Spannagl M, Fritz H, Schramm W, Recombinant hirudin: effects of single and repeated subcutaneous administrations of different doses in healthy volunteers. Drug Res., submitted

4. Bichler J, Gemmerli R, Fritz H (1991) Studies for revealing a possible sensitization to hirudin after repeated intravenous injections in baboons. Thromb Res 61: 39–51

5. Bichler J, Siebeck M, Maschler R, Pelzer H, Fritz H (1991) Determination of hirudin-thrombin complex in plasma with an enzyme-linked immunosorbent assay. Blood Coagulation Fibrinolysis 2: 129–133

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