Development of a sensitive and quantitative capillary LC-UV method to study the uptake of pharmaceuticals in zebrafish brain
Author:
Funder
EU FP7 ITN
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry,Analytical Chemistry
Link
http://link.springer.com/article/10.1007/s00216-018-0955-4/fulltext.html
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3. Reichel A. Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept. Chem Biodivers. 2009;6:2030–49. https://doi.org/10.1002/cbdv.200900103 .
4. Hitchcock SA. Blood-brain barrier permeability considerations for CNS-targeted compound library design. Curr Opin Chem Biol. 2008;12:318–23. https://doi.org/10.1016/j.cbpa.2008.03.019 .
5. Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol Dis. 2010;37:48–57. https://doi.org/10.1016/j.nbd.2009.07.028 .
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