MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix

Author:

Jia Qianqian,Fu Jia,Gao Chunlei,Wang Hong,Wang Saisai,Liang Peida,Han Shengli,Lv YanniORCID,He Langchong

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry,Analytical Chemistry

Reference29 articles.

1. Szebeni J. Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity. Toxicology. 2005;216(2–3):106–21. https://doi.org/10.1016/j.tox.2005.07.023.

2. McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015;519(7542):237–41. https://doi.org/10.1038/nature14022.

3. Wolf K, Kühn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, Ständer S, Ectors P, Zahn D, Riedel YK, Thimm D, Müller CE, Kretschmann S, Kremer AN, Chien D, Limjunyawong N, Peng Q, Dong X, Kolkhir P, Scheffel J, Søgaard ML, Weigmann B, Neurath MF, Hawro T, Metz M, Fischer MJM, Kremer AE. A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice. J Allergy Clin Immunol. 2021;148(2):506-522.e8. https://doi.org/10.1016/j.jaci.2020.12.655.

4. Li Q, Zhang L, Gu L, Zhang B, Lu J, Zhang X. Pseudo-allergic reaction caused by Qingkailing injection partially via the PI3K-Rac1 signaling pathway in RBL-2H3 cells. Toxicol Res (Camb). 2019;8(3):353–60. https://doi.org/10.1039/c8tx00306h.

5. Sun W, Wang S, Liang P, Zhou H, Zhang L, Jia Q, Fu J, Lv Y, Han S. Pseudo-allergic compounds screened from Shengmai injection by using high-expression Mas-related G protein-coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry. J Sep Sci. 2021;44(7):1421–9. https://doi.org/10.1002/jssc.202001163.

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