Metabolites profiling of 10 bufadienolides in human liver microsomes and their cytotoxicity variation in HepG2 cell-Reference-Cited by-同舟云学术

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Metabolites profiling of 10 bufadienolides in human liver microsomes and their cytotoxicity variation in HepG2 cell

Published:2016-02-11 Issue:10 Volume:408 Page:2485-2495
ISSN:1618-2642
Container-title:Analytical and Bioanalytical Chemistry
language:en
Short-container-title:Anal Bioanal Chem

Author:

Han Lingyu,Wang Hongjie,Si Nan,Ren Wei,Gao Bo,Li Yan,Yang Jian,Xu Miao,Zhao Haiyu,Bian Baolin

Funder

Special Program for New Drug Innovation of the Ministry of Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry,Analytical Chemistry

Link

http://link.springer.com/content/pdf/10.1007/s00216-016-9345-y.pdf

Reference33 articles.

1. Gao HM, Popesco R, Kopp B, Wang ZM. Bufadienolides and their antitumor activity. Nat Prod Rep. 2011;28:953–69.

2. Wang DL, Qi FH, Tang W. Chemical constituents and bioactivities of the skin of Bufo bufo gaigarizan Cantor. Chem Biodivers. 2011;8:559–67.

3. Nogawa T, Kamano Y, Yamashita A, Pettit GR. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch’an Su. J Nat Prod. 2001;64:1148–52.

4. Yeh JY, Huang WJ, Kan SF, Wang PS. Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells. Prostate. 2003;54:112–24.

5. Kamano Y, Kotake A, Hashima H, Inoue M, Morita H, Takeya K, et al. Structure-cytotoxic activity relationship for the toad poison bufadienolides. Bioorgan Med Chem. 1998;6:1103–15.

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