Digital microfluidic immobilized cytochrome P450 reactors with integrated inkjet-printed microheaters for droplet-based drug metabolism research-Reference-Cited by-同舟云学术

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Digital microfluidic immobilized cytochrome P450 reactors with integrated inkjet-printed microheaters for droplet-based drug metabolism research

Published:2018-08-02 Issue:25 Volume:410 Page:6677-6687
ISSN:1618-2642
Container-title:Analytical and Bioanalytical Chemistry
language:en
Short-container-title:Anal Bioanal Chem

Author:

Sathyanarayanan Gowtham,Haapala Markus,Kiiski Iiro,Sikanen Tiina

Funder

Doctoral programme in drug research, University of Helsinki

University of Helsinki Funds

University of Helsinki Research Foundation

Suomen Akatemia

European Research Council (ERC/FP7)

Centre for International Mobility (CIMO)

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry,Analytical Chemistry

Link

http://link.springer.com/article/10.1007/s00216-018-1280-7/fulltext.html

Reference39 articles.

1. Guengerich FP. Cytochrome P450 and chemical toxicology. Chem Res Toxicol. 2008;21:70–83. https://doi.org/10.1021/tx700079z .

2. Zanger UM, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem. 2008;392:1093–108. https://doi.org/10.1007/s00216-008-2291-6 .

3. Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138:103–41. https://doi.org/10.1016/j.pharmthera.2012.12.007 .

4. Bajorath J. Integration of virtual and high-throughput screening. Nat Rev Drug Discov. 2002;1:882–94. https://doi.org/10.1038/nrd941 .

5. Ruokolainen M, Gul T, Permentier H, Sikanen T, Kostiainen R, Kotiaho T. Comparison of TiO2 photocatalysis, electrochemically assisted Fenton reaction and direct electrochemistry for simulation of phase I metabolism reactions of drugs. Eur J Pharm Sci. 2016;83:36–44. https://doi.org/10.1016/j.ejps.2015.12.012 .

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