In vitro assessment ofN-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance

Author:

Finlay Graeme J.,Marshall Elaine,Matthews John H. L.,Paull Kenneth D.,Baguley Bruce C.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference27 articles.

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2. Atwell GJ, Rewcastle GW, Baguley BC, Denny WA (1987) Potential antitumor agents: 50. In vivo solid tumor activity of derivatives ofN-[2-(dimethylamino)ethyl]-acridine-4-carboxamide. J Med Chem 30: 664?669

3. Baguley BC, Holdaway KM, Fray LM (1990) Design of DNA intercalators to overcome topoisomerase II-mediated multidrug resistance. J Natl Cancer Inst 82: 398?402

4. Beck WT (1987) The cell biology of multiple drug resistance. Biochem Pharmacol 36: 2879?2888

5. Deffie AM, Alam T, Seneviratne C, Beenken SW, Batra JK, Shea TC, Henner WD, Geldenberg GJ (1988) Multifactorial resistance to Adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of Adriamycin-sensitive and-resistant P388 leukemia. Cancer Res 48: 3595?3602

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