Research progress and application of two-dimensional materials for surface-enhanced Raman scattering

Abstract

AbstractSurface Enhanced Raman Scattering (SERS) is a pivotal detection technology that identifies molecular spectral signals at the single-molecule level. Owing to its sensitivity and non-destructive nature, SERS has found extensive applications in diverse fields such as environmental science, medical diagnosis, food safety, and bioanalysis. In recent years, two-dimensional materials have emerged as one prominent novel SERS-active nanomaterials due to their unique physical and chemical properties. This paper provides a comprehensive review of the enhancement mechanism of SERS, substrate preparation, and its applications in biosensing, environmental detection, and food safety. It delves into the widely accepted basic theory and enhancement mechanism of SERS, along with common methods to boost SERS performance, including doping with other elements, applying stress and strain, forming defects, and amorphous processing. This paper examines the current state of research on two-dimensional(2D) materials and their application in the field of SERS. Additionally, it provides an viewpoints on recent advancements in the use of this technology for virus and cancer detection. Lastly, it discusses the future prospects for the development of SERS technology.