Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity-Reference-Cited by-同舟云学术

Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity

Published:2021-03-03 Issue:3 Volume:24 Page:647-656
ISSN:0969-6970
Container-title:Angiogenesis
language:en
Short-container-title:Angiogenesis

Author:

Kanugula Anantha K.,Adapala Ravi K.,Jamaiyar Anurag,Lenkey Nina,Guarino Brianna D.,Liedtke Wolfgang,Yin Liya,Paruchuri Sailaja,Thodeti Charles K.^ORCID

Funder

National Cancer Institute

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Clinical Biochemistry,Physiology

Link

https://link.springer.com/content/pdf/10.1007/s10456-021-09775-9.pdf

Reference34 articles.

1. Adapala RK, Thoppil RJ, Ghosh K, Cappelli HC, Dudley AC, Paruchuri S, Keshamouni V, Klagsbrun M, Meszaros JG, Chilian WM, Ingber DE, Thodeti CK (2016) Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. Oncogene 35(3):314–322. https://doi.org/10.1038/onc.2015.83

2. Adapala RK, Thoppil RJ, Luther DJ, Paruchuri S, Meszaros JG, Chilian WM, Thodeti CK (2013) TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol 54:45–52. https://doi.org/10.1016/j.yjmcc.2012.10.016

3. Cappelli HC, Kanugula AK, Adapala RK, Amin V, Sharma P, Midha P, Paruchuri S, Thodeti CK (2019) Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis. Cancer Lett 442:15–20. https://doi.org/10.1016/j.canlet.2018.07.042

4. Hartmannsgruber V, Heyken WT, Kacik M, Kaistha A, Grgic I, Harteneck C, Liedtke W, Hoyer J, Kohler R (2007) Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One 2(9):e827

5. Liedtke W (2005) TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J Physiol 567(Pt 1):53–58

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