The use of high dose d,l-leucovorin in first-line bevacizumab+mFOLFIRI treatment of patients with metastatic colorectal cancer may enhance the antiangiogenic effect of bevacizumab

Author:

Budai B.,Nagy T.,Láng I.,Hitre E.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Clinical Biochemistry,Physiology

Reference48 articles.

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2. Zhao Z, Pelletier E, Barber B et al (2012) Patterns of treatment with chemotherapy and monoclonal antibodies for metastatic colorectal cancer in Western Europe. Curr Med Res Opin 28:221–229

3. Odabas H, Ozdemir N, Abali H et al (2011) First-line therapy for metastatic colorectal carcinoma: modified FOLFOX4 or FOLFIRI-bevacizumab. J BUON 16:247–252

4. Koutras AK, Antonacopoulou AG, Eleftheraki AG et al (2011) Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab. Pharmacogenomics J. doi: 10.1038/tpj.2011.37

5. Dranitsaris G, Edwards S, Edwards J et al (2010) Bevacizumab in combination with FOLFIRI chemotherapy in patients with metastatic colorectal cancer: an assessment of safety and efficacy in the province of Newfoundland and Labrador. Curr Oncol 17:12–16

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