Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration

Author:

Adams Gregory P.,McCartney John E.,Wolf Ellen J.,Eisenberg Jamie,Tai Mei-Sheng,Huston James S.,Stafford Walter F.,Bookman Michael A.,Houston L. L.,Weiner Louis M.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Reference23 articles.

1. Adams GP, DeNardo SJ, Deshpande SV, DeNardo GL, Meares CF, McCall MJ, Epstein AL (1989) Effect of mass of111Inbenzyl-EDTA monoclonal antibody on hepatic uptake and processing in mice. Cancer Res 49:1707

2. Adams GP, DeNardo SJ, Amin A, Kroger LA, DeNardo GL, Hellstrom I, Hellstrom KE (1992) Comparison of the pharmacokinetics in mice and the biological activity of murine L6 and human-mouse chimeric Ch-L6 antibody. Antibody Immunoconjugates Radiopharm 5:81

3. Adams GP, McCartney JE, Tai M-S, Oppermann H, Huston JS, Stafford III WF, Bookman MA, Fand I, Houston LL, Weiner LM (1993) Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. Cancer Res 53:4026

4. Beaumier PL, Neuzil D, Yang H-M, Noll EA, Kishore R, Eary JF, Krohn KA, Nelp WJ, Hellstrom KE, Hellstrom J (1986) Immunoreactivity assay for labeled anti-melanoma monoclonal antibodies. J Nucl Med 27:824

5. Bird RE, Hardman KD, Jacobson JW, Johnson S, Kaufman BM, Lee S-M, Lee T, Pope SH, Riordan GS, Whitlow M (1988) Single-chain antigen-binding proteins. Science 242:423

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