Low temperatures stabilize interferon ?-2 against proteolysis in Methylophilus methylotrophus and Escherichia coli

Author:

Chesshyre Julian A.,Hipkiss Alan R.

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,General Medicine,Biotechnology

Reference23 articles.

1. Boss MA, Kenton JH, Wood CR, Emtage JS (1984) Assembly of functional antibodies from immunoglobin heavy and light chains synthesized in E. coli. Nucleic Acids Res 12:3792?3806

2. Carrier MJ, Nugent ME, Tacon WCA, Primrose SB (1983) High expression of cloned genes in E. coli and its consequences. Trends Biotechnol 1:109?113

3. Chesshyre JA, Carr AJ, Hipkiss AR (1987) Proteolysis in the obligate methylotroph Methylophilus methylotrophus. Arch Microbiol 147:394?398

4. Edge MD, Camble R, Moore VE, Hockney RC, Carr FJ, Fitton J (1986) Interferon analogues from synthetic genes: an approach to protein structure-activity studies. In: Gresser I (ed) Interferon 7. Academic Press, London, pp 1?47

5. Goff S, Goldberg AL (1985) Production of abnormal proteins in Escherichia coli stimulates transcription of lon and other heat shock genes. Cell 41:589?595

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