Associations Between Anticholinergic Medication Exposure and Adverse Health Outcomes in Older People with Frailty: A Systematic Review and Meta-analysis

Author:

Mehdizadeh DavidORCID,Hale Matthew,Todd Oliver,Zaman Hadar,Marques Iuri,Petty Duncan,Alldred David P.,Johnson Owen,Faisal Muhammad,Gardner Peter,Clegg Andrew

Funder

National Institute for Health Research (NIHR) Yorkshire and Humber Patient Safety Translational Research Centre

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical)

Reference70 articles.

1. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62. https://doi.org/10.1016/S0140-6736(12)62167-9.

2. Mangoni AA, Jackson SHD. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57(1):6–14. https://doi.org/10.1046/j.1365-2125.2003.02007.x.

3. Hilmer SN, Gnjidic D, Le Couteur DG. Thinking through the medication list: appropriate prescribing and deprescribing in robust and frail older patients. Aust Fam Physician. 2012;41(12):924.

4. Clegg A, Young J. The frailty syndrome. Clin Med (Lond). 2011;11(1):72–5. https://doi.org/10.7861/clinmedicine.11-1-72.

5. Moody D, Lyndon H, Stevens G. Toolkit for general practice in supporting older people living with frailty. NHS Engl. 2017;1(2):8–14.

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