Can 5-HT3 Antagonists Really Contribute to Serotonin Toxicity? A Call for Clarity and Pharmacological Law and Order

Author:

Rojas-Fernandez Carlos H.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical)

Reference15 articles.

1. Summary safety review-serotonin blocking drugs (serotonin antagonists) Aloxi (palonosetron), Anzemet (dolasetron), Kytril (granisetron) and generics, and Zofran (ondansetron) and generics-Serotonin Syndrome. Available at: http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/review-examen/serotonin-eng.php . Accessed May 29th 2014.

2. WHO pharmaceutical newsletter: ondansetron and serotonin syndrome. 2012;3:16–21.

3. Kytrtil 5HT3 safety review. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM342225.pdf . Accessed 29 May 2014.

4. Gillman PK. A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biol Psych. 2006;59:1046–51.

5. Gillman PK. CNS toxicity involving methylene blue: the exemplar for understanding and predicting drug interactions that precipitate serotonin toxicity. J Psychopharmacol. 2011;25:429–36.

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