Adineta vaga under fire: simulating the impact of radiation
-
Published:2023-08-16
Issue:
Volume:
Page:
-
ISSN:0018-8158
-
Container-title:Hydrobiologia
-
language:en
-
Short-container-title:Hydrobiologia
Author:
Perrot Alexandre, Hespeels BorisORCID, Van Doninck Karine, Heuskin Anne-Catherine
Abstract
AbstractPrevious studies have demonstrated the remarkable resistance of bdelloid rotifers to ionizing radiation, making them an interesting model system for studying radiation effects on living organisms. In this study, we use simulations, instead of direct experimental exposures, to examine whether all bdelloids are affected equally by radiation exposure and to explore the relationship between biological data and energy deposition patterns induced by low and high linear energy transfer (LET) radiation. To this end, tool for particle simulation (TOPAS) a simulation tool, widely used in the field of medical physics and radiation therapy, was utilized. Using simulations for proton, iron ions, and X-ray exposure, our findings showed that all individuals, cells, and nuclei were effectively hit by the administered doses of 4 MeV protons, 0.5 GeV/n 56Fe, and X-ray radiation. The results support that the impact on survival and fertility rate measured in Adineta vaga is caused by radiation-induced damage rather than the absence of hits in certain individuals or germinal cells. Notably, simulations revealed significant differences between low- and high-LET radiation concerning irradiated individuals' nuclei. Specifically, for an equivalent dose, high-LET radiation requires fewer incident particles compared to low-LET radiation, resulting in a sparser distribution of radiation hits on the nucleus surface. In conclusion, the study supports the idea that reduced fertility described in high-LET exposed samples is associated with complex DNA damage caused by the condensed energy deposition pattern of high-LET radiation compared to low-LET.
Publisher
Springer Science and Business Media LLC
Reference50 articles.
1. Agostinelli, S., J. Allison, K. Amako, J. Apostolakis, H. Araujo, P. Arce, M. Asai, D. Axen, S. Banerjee, G. Barrand, F. Behner, L. Bellagamba, J. Boudreau, L. Broglia, A. Brunengo, H. Burkhardt, S. Chauvie, J. Chuma, R. Chytracek, G. Cooperman, G. Cosmo, P. Degtyarenko, A. Dell’Acqua, G. Depaola, D. Dietrich, R. Enami, A. Feliciello, C. Ferguson, H. Fesefeldt, G. Folger, F. Foppiano, A. Forti, S. Garelli, S. Giani, R. Giannitrapani, D. Gibin, J. J. Gómez Cadenas, I. González, G. Gracia Abril, G. Greeniaus, W. Greiner, V. Grichine, A. Grossheim, S. Guatelli, P. Gumplinger, R. Hamatsu, K. Hashimoto, H. Hasui, A. Heikkinen, A. Howard, V. Ivanchenko, A. Johnson, F. W. Jones, J. Kallenbach, N. Kanaya, M. Kawabata, Y. Kawabata, M. Kawaguti, S. Kelner, P. Kent, A. Kimura, T. Kodama, R. Kokoulin, M. Kossov, H. Kurashige, E. Lamanna, T. Lampén, V. Lara, V. Lefebure, F. Lei, M. Liendl, W. Lockman, F. Longo, S. Magni, M. Maire, E. Medernach, K. Minamimoto, P. Mora de Freitas, Y. Morita, K. Murakami, M. Nagamatu, R. Nartallo, P. Nieminen, T. Nishimura, K. Ohtsubo, M. Okamura, S. O’Neale, Y. Oohata, K. Paech, J. Perl, A. Pfeiffer, M. G. Pia, F. Ranjard, A. Rybin, S. Sadilov, E. Di Salvo, G. Santin, T. Sasaki, N. Savvas, Y. Sawada, S. Scherer, S. Sei, V. Sirotenko, D. Smith, N. Starkov, H. Stoecker, J. Sulkimo, M. Takahata, S. Tanaka, E. Tcherniaev, E. Safai Tehrani, M. Tropeano, P. Truscott, H. Uno, L. Urban, P. Urban, M. Verderi, A. Walkden, W. Wander, H. Weber, J. P. Wellisch, T. Wenaus, D. C. Williams, D. Wright, T. Yamada, H. Yoshida & D. Zschiesche, 2003. Geant4—a simulation toolkit. Nuclear Instruments and Methods in Physics Research Section A 506: 250–303. 2. Allison, J., K. Amako, J. Apostolakis, H. Araujo, P. Arce Dubois, M. Asai, G. Barrand, R. Capra, S. Chauvie, R. Chytracek, G. A. P. Cirrone, G. Cooperman, G. Cosmo, G. Cuttone, G. G. Daquino, M. Donszelmann, M. Dressel, G. Folger, F. Foppiano, J. Generowicz, V. Grichine, S. Guatelli, P. Gumplinger, A. Heikkinen, I. Hrivnacova, A. Howard, S. Incerti, V. Ivanchenko, T. Johnson, F. Jones, T. Koi, R. Kokoulin, M. Kossov, H. Kurashige, V. Lara, S. Larsson, F. Lei, O. Link, F. Longo, M. Maire, A. Mantero, B. Mascialino, I. McLaren, P. Mendez Lorenzo, K. Minamimoto, K. Murakami, P. Nieminen, L. Pandola, S. Parlati, L. Peralta, J. Perl, A. Pfeiffer, M. G. Pia, A. Ribon, P. Rodrigues, G. Russo, S. Sadilov, G. Santin, T. Sasaki, D. Smith, N. Starkov, S. Tanaka, E. Tcherniaev, B. Tome, A. Trindade, P. Truscott, L. Urban, M. Verderi, A. Walkden, J. P. Wellisch, D. C. Williams, D. Wright & H. Yoshida, 2006. Geant4 developments and applications. IEEE Transactions on Nuclear Science 53: 270–278. 3. Allison, J., K. Amako, J. Apostolakis, P. Arce, M. Asai, T. Aso, E. Bagli, A. Bagulya, S. Banerjee, G. Barrand, B. R. Beck, A. G. Bogdanov, D. Brandt, J. M. C. Brown, H. Burkhardt, P. Canal, D. Cano-Ott, S. Chauvie, K. Cho, G. A. P. Cirrone, G. Cooperman, M. A. Cortés-Giraldo, G. Cosmo, G. Cuttone, G. Depaola, L. Desorgher, X. Dong, A. Dotti, V. D. Elvira, G. Folger, Z. Francis, A. Galoyan, L. Garnier, M. Gayer, K. L. Genser, V. M. Grichine, S. Guatelli, P. Guèye, P. Gumplinger, A. S. Howard, I. Hřivnáčová, S. Hwang, S. Incerti, A. Ivanchenko, V. N. Ivanchenko, F. W. Jones, S. Y. Jun, P. Kaitaniemi, N. Karakatsanis, M. Karamitros, M. Kelsey, A. Kimura, T. Koi, H. Kurashige, A. Lechner, S. B. Lee, F. Longo, M. Maire, D. Mancusi, A. Mantero, E. Mendoza, B. Morgan, K. Murakami, T. Nikitina, L. Pandola, P. Paprocki, J. Perl, I. Petrović, M. G. Pia, W. Pokorski, J. M. Quesada, M. Raine, M. A. Reis, A. Ribon, A. Ristić Fira, F. Romano, G. Russo, G. Santin, T. Sasaki, D. Sawkey, J. I. Shin, I. I. Strakovsky, A. Taborda, S. Tanaka, B. Tomé, T. Toshito, H. N. Tran, P. R. Truscott, L. Urban, V. Uzhinsky, J. M. Verbeke, M. Verderi, B. L. Wendt, H. Wenzel, D. H. Wright, D. M. Wright, T. Yamashita, J. Yarba & H. Yoshida, 2016. Recent developments in Geant4. Nuclear Instruments and Methods in Physics Research Section A 835: 186–225. 4. Alloni, D., A. Campa, W. Friedland, L. Mariotti & A. Ottolenghi, 2013. Integration of Monte Carlo simulations with PFGE experimental data yields constant RBE of 2.3 for DNA double-strand break induction by nitrogen ions between 125 and 225 keV/μm LET. Radiation Research 179: 690–697. 5. Alpert, P., 2005. The limits and frontiers of desiccation-tolerant life. Integrative and Comparative Biology 45: 685–695.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|