A phase II study of α-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma

Author:

Meyskens Frank L.,Kingsley Edwin M.,Glattke Theodore,Loescher Lois,Booth Ann

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference16 articles.

1. Comis RL: DTIC (NSC-45388) in malignant melanoma: a perspective. Cancer Treat Rep 60:165–176, 1976

2. Mamont PS, Duchesne M, Juder-Ohlenbusch A, Grove J: Effects of ornithine decarboxylase inhibitors on cultured cells. In: Seller N, Jung MJ, Koch-Weser J (eds): Enzyme-activated irreversible inhibitors, Vol. 3. Elsevier/North- Holland Biomedical Press, Amsterdam, 1978, pp 43–53

3. Metcalf BW, Bey P, Danzin C, Jung MJ, Casara P, Vevert JP: Catalytic irreversible inhibition of mammalian ornithine decarboxylase (EC 4.1.1.17) by substrate and product analogues. J Am Chem Soc 100:2551–2553, 1978

4. Pegg AE, McCann PP: Polyamine metabolism and function. Am J Physiol 243 (Cell Physiol 12):C212-C221, 1982

5. Mamont PS, Duchesne MC, Grove J, Bey J: Antiproliferative properties of D, L-α-difluoromethylornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase. Biochem Biophys Res Commun 81:58–66, 1978

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