Explainable machine learning via intra-tumoral radiomics feature mapping for patient stratification in adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma

Author:

Teng Xinzhi,Zhang Jiang,Han Xinyang,Sun Jiachen,Lam Sai-Kit,Ai Qi-Yong Hemis,Ma Zongrui,Lee Francis Kar-Ho,Au Kwok-Hung,Yip Celia Wai-Yi,Chow James Chung Hang,Lee Victor Ho-Fun,Cai Jing

Funder

Mainland-Hong Kong Joint Funding Scheme

Shenzhen-Hong Kong-Macau S&T Program

Shenzhen Basic Research Program

Project of Strategic Importance Fund

Project of RISA

Health and Medical Research Fund

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

Reference24 articles.

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2. Caudell JJ, Gillison ML, Maghami E, Spencer S, Pfister DG, Adkins D, Birkeland AC, Brizel DM, Busse PM, Cmelak AJ, Colevas AD, Eisele DW, Galloway T, Geiger JL, Haddad RI, Hicks WL Jr, Hitchcock YJ, Jimeno A, Leizman D, Mell LK, Mittal BB, Pinto HA, Rocco JW, Rodriguez CP, Savvides PS, Schwartz D, Shah JP, Sher D, St. John M, Weber RS, Weinstein G, Worden F, Yang Bruce J, Yom SS, Zhen W, Burns JL, Darlow SD, (2022) NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022. J Nat Compr Cancer Netw 20:224–234. https://doi.org/10.6004/jnccn.2022.0016

3. Aerts HJWL, Velazquez ER, Leijenaar RTH, Parmar C, Grossmann P, Cavalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F, Rietbergen MM, Leemans CR, Dekker A, Quackenbush J, Gillies RJ, Lambin P (2014) Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun 5:4006. https://doi.org/10.1038/ncomms5006

4. Peng H, Dong D, Fang M-J, Li L, Tang L-L, Chen L, Li W-F, Mao Y-P, Fan W, Liu L-Z, Tian L, Lin A-H, Sun Y, Tian J, Ma J (2019) Prognostic value of deep learning PET/CT-based radiomics: potential role for future individual induction chemotherapy in advanced nasopharyngeal carcinoma. Clin Cancer Res 25:4271–4279. https://doi.org/10.1158/1078-0432.CCR-18-3065

5. Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J (2021) A deep learning-based radiomic nomogram for prognosis and treatment decision in advanced nasopharyngeal carcinoma: a multicentre study. EBioMedicine. https://doi.org/10.1016/j.ebiom.2021.103522

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