NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b-Reference-Cited by-同舟云学术

NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b

Published:2023-04-29 Issue:1 Volume:17 Page:135-142
ISSN:1874-2718
Container-title:Biomolecular NMR Assignments
language:en
Short-container-title:Biomol NMR Assign

Author:

Hargittay Bruno,Mineev Konstantin S.,Richter Christian,Sreeramulu Sridhar,Jonker Hendrik R.A.,Saxena Krishna,Schwalbe Harald

Abstract

AbstractThe splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic development. Here, we report the almost complete NMR chemical shift assignment of the backbone and aliphatic side chains of FGF8b. Obtained chemical shifts are in good agreement with the previously reported X-ray data, excluding the N-terminal gN helix, which apparently forms only in complex with the receptor. The reported data provide an NMR starting point for the investigation of FGF8b interaction with its receptors and with potential drugs or inhibitors.

Funder

Johann Wolfgang Goethe-Universität, Frankfurt am Main

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry,Structural Biology

Link

https://link.springer.com/content/pdf/10.1007/s12104-023-10132-8.pdf

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