Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats

Author:

H�nack Dagmar,Rundfeldt Chris,L�scher Wolfgang

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference33 articles.

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2. Freeman FG, Jarvis MF (1981) The effect of interstimulation interval on the assessment and stability of kindled seizure thresholds. Brain Res Bull 7: 629?633

3. H�nack D, L�scher W (1989) Amygdala-kindling as a model for chronic efficacy studies on antiepileptic drugs: Experiments with carbamazepine. Neuropharmacology 28: 599?610

4. Kalant H, Khanna JM (1990) Methods for the study of tolerance. In: Adler MW, Cowan A (eds) Modern methods in pharmacology, vol 6: testing and evaluation of drugs of abuse. Wiley-Liss, New York, pp 43?66

5. Kesterson JW, Grannemann GR, Machinist JM (1984) The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies. Hepatology 4: 1143?1152

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