Abstract
AbstractKaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent
associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric
Castleman disease. It has been shown that high KSHV prevalence and high incidence of
both classic KS and AIDSassociated KS are found mostly among people of Uygur
ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV
seroprevalence than those of other Han populations in mainland China. However, it is
still unclear why there is such geographical and population variation in KSHV
distribution in China. In this work, we focused on the populations in the Kashgar
region and Urumqi area, where a total of 1294 research subjects were randomly
selected to investigate the potential correlation between KSHV prevalence and
different ethnicities in endemic areas of Xinjiang, and to determine risk factors
that may affect KSHV infection rates or KS incidence. We identified a high
seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur
and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined
that advancing age, low education level, and stationary population status affect
KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have
higher prevalence of neutralizing antibodies and neutralizing antibody titers than
KSHV-positive Han participants.
Subject
Virology,Molecular Medicine,Immunology
Cited by
16 articles.
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