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The Effect of Hepatic Impairment on the Pharmacokinetics of Dacomitinib

  • Published:2022-02-23 Issue:3 Volume:42 Page:221-235
  • ISSN:1173-2563
  • Container-title:Clinical Drug Investigation
  • language:en
  • Short-container-title:Clin Drug Investig

Author:

Piscitelli Joseph,Chen Joseph,LaBadie Robert R.,Salageanu Joanne,Chung Chin-Hee,Tan Weiwei

Funder

Pfizer

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Reference32 articles.

1. Fukuoka M, Wu YL, Thongprasert S, Sunpaweravong P, Leong SS, Sriuranpong V, et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol. 2011;29:2866–74. https://doi.org/10.1200/JCO.2010.33.4235.

2. Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362:2380–8. https://doi.org/10.1056/NEJMoa0909530.

3. Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11:121–8. https://doi.org/10.1016/S1470-2045(09)70364-X.

4. Sequist LV, Yang JC, Yamamoto N, O’Byrne K, Hirsh V, Mok T, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31:3327–34. https://doi.org/10.1200/JCO.2012.44.2806.

5. Wu YL, Zhou C, Hu CP, Feng J, Lu S, Huang Y, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol. 2014;15:213–22. https://doi.org/10.1016/S1470-2045(13)70604-1.

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