A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives

Author:

Dotsenko Victor V.,Krivokolysko Sergey G.,Litvinov Victor P.

Publisher

Springer Science and Business Media LLC

Subject

General Chemistry

Reference39 articles.

1. For detailed reviews of 3,7-diazabicyclo[3.3.1]nonane chemistry see: a) Zefirov NS, Rogozina SV (1973) Russ Chem Rev 42: 190;

2. b) Jeyaraman R, Aliva S (1981) Chem Rev 81: 149;

3. c) Zefirov NS, Palyulin VA (1991) Conformational Analysis of Bicyclo[3.3.1]nonanes and Their Hetero Analogs. In: Eliel EL, Wilen SH (eds) Topics in Stereochemistry, vol 20. Interscience-Wiley, Publishers, New York, p 171

4. Synthesis and antitumor properties of 1,3-diaza-2-phosphaadamantane derivatives, phosphoryl-containing 3,7-diazabicyclo[3.3.1]nonane, and 1,3-diazaajdamantane

5. a) Berlin KD, Garrison GL, Sangiah S, Clarke CR, Chen Ch-L, Lazzara R, Scherlag BJ, Patterson ES, Burrows GE (1995) US Pat 5468858; Avail. URL http://patft.uspto.gov/netahtml/srchnum.htm ; b) Garrison GL, Berlin KD, Scherlag BJ, Lazzara R, Patterson E, Fazekas T, Sangiah S, Chen CL, Schubot FD, van der Helm D (1996) J Med Chem 39: 2559; c) Smith GS, Thompson MD, Berlin KD, Holt EM, Scherlag BJ, Patterson E, Lazzara R (1990) Eur J Med Chem 25: 1; d) Ruenitz PC, Moker CM (1977) J Med Chem 20: 1668; e) Berlin KD, Scherlag BJ, Clarke CR, Otiv SR, Zisman SA, Sangiah S, Mulekar SV (1992) US Pat 5084572; Avail. URL http://patft.uspto.gov/netahtml/srchnum.htm

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