Abstract
AbstractThe reaction of 2,3-dihydropyridines with sulfonyl halides surprisingly yielded open chain dienes with sulfonylimine structure. The products were specific out of several possible isomers and, therefore, a separation of isomers was not necessary. All new compounds were characterized using FT-IR spectroscopy, HRMS, and NMR spectroscopy. A bicyclic by-product from the reaction of a 2,3-dihydropyridine with mesyl chloride was isolated and its structure elucidated using a single X-ray crystal analysis. Some biological activities, like antimicrobial and cytotoxic properties were investigated.
Graphic abstract
Publisher
Springer Science and Business Media LLC
Reference25 articles.
1. Zhou L, Yuan C, Zeng Y, Liu H, Wang C, Gao X, Wang Q, Zhang C, Guo H (2018) Chem Sci 9:1831
2. Ewies EF, El-Hag FAA (2020) J Heterocycl Chem 57:163
3. Jalali H, Hosseini SJ, Ali-Asgari S, Nia JI (2020) J Heterocycl Chem 57:419
4. Capretz-Agy A, Fernandes FS, Rodrigues MT, Conti C, Coelho F (2019) Synlett 30:A-E
5. Gu Z, Wu B, Jiang G-F, Zhou Y-G (2018) Chin J Chem 36:1130