Straightforward Synthesis of (R,S)-β-Methyleneaspartic Acid, an Inhibitor of Glutamate-Aspartate Transaminase

Author:

Galeazzi Roberta,Martelli Gianluca,Orena Mario,Rinaldi Samuele

Publisher

Springer Science and Business Media LLC

Subject

General Chemistry

Reference13 articles.

1. Hanessian S, McNaughton-Smith G, Lombart HG, Lubell WD (1997) Tetrahedron 53: 12789; for lead references, see also: Hruby VJ, Soloshonok VA, Eds. (2001) Asymmetric Synthesis of Novel Sterically Constrained Amino Acids; Symposium-in-Print, Tetrahedron 57: 6329

2. a) Gante J (1994) Angew Chem Int Ed Engl 33: 1699; b) Hruby VJ, Balse PM (2000) Curr Med Chem 7: 945; c) Palczewski K, Kumassaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M (2000) Science 289: 739

3. a) Cooper AJL, Fitzpatrick SM (1982) J Am Chem Soc 104: 332; b) King S, Phillips AT (1978) J Neurochem 30: 1399; c) Dowd P, Kaufman C (1979) J Org Chem 44: 3956

4. .beta.-Methylene-DL-asparagine

5. a) Stirling DI (1992) The use of aminotransferases for the production of chiral amino acids and amines. In: Collins AN, Sheldrake GN, Crosby J (Eds) Chirality in Industry, John Wiley & Sons, New York, p 209; b) Taylor PP, Pantaleone DP, Senkpeil RF, Fotheringham IG (1998) Trends Biotechnol 16: 412

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