Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study
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Published:2023-02-20
Issue:8
Volume:38
Page:2631-2641
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ISSN:0931-041X
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Container-title:Pediatric Nephrology
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language:en
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Short-container-title:Pediatr Nephrol
Author:
Groen in ‘t Woud Sander, Roeleveld Nel, van Rooij Iris A. L. M., Feitz Wout F. J., Schreuder Michiel F., van der Zanden Loes F. M.ORCID, van Wijk J. A. E., Westland R., Renkema K. Y., Lilien M. R., Keijzer-Veen M. G., Kloosterman F. J., Steffens M. G., Gracchi V., Zegers B., Jira P. E., van der Deure H., van Rooij R. W. G., Wijnands - van den Berg E., Breukels M., de Pont S. M. H. B., Harnisch E., van Dael C. M. L., Creemers D., de Moor R., Konijnenberg A. Y., Knots E., van der Kuur E. C., Jacobs M. J., Koppejan-Stapel M., Pijning A., Dorresteijn E., Leunissen R. W. J., Rijlaarsdam R., del Canho R., Semmekrot B., Dings-Lammertink A., Nijhuis I. J. M., van Ledden-Klok M. J., van den Broek L. M., Jansen C. Meine, Beeren M. C. G., Blokland-Loggers H. E., Dorrepaal C., Pierik L. J. W. M., Tanja A. L.,
Abstract
Abstract
Background
The etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors. We performed a case–control study to compare exposure to environmental and parental risk factors during embryonic kidney development between children with CSFK and healthy controls.
Methods
We included 434 children with CSFK and 1302 healthy controls from the AGORA data- and biobank matched on year of birth. Exposure to potential risk factors was investigated using parental questionnaire data. Crude and adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were estimated for each potential risk factor. Multiple imputation was used to deal with missing values. Confounders for each potential risk factor were selected using directed acyclic graphs.
Results
Maternal stress was newly identified as a risk factor for CSFK (aOR 2.1, 95% CI 1.2–3.5). Known associations with conception using in vitro fertilization/intracytoplasmic sperm injection (aOR 1.8, 95% CI 1.0–3.2), maternal infections during pregnancy (aOR 2.5, 95% CI 1.4–4.7), smoking during pregnancy (aOR 1.4, 95% CI 1.0–2.0), and parental CAKUT (aOR 6.6, 95% CI 2.9–15.1) were confirmed, but previous associations with diabetes and obesity could not be replicated. Folic acid supplement use and younger maternal age seemed to reduce the risk of CSFK (aORs 0.7, 95% CI 0.5–1.0, and 0.8, 95% CI 0.6–1.0, respectively).
Conclusions
Environmental and parental risk factors are likely to be involved in the development of CSFK and future studies should combine genetic, environmental, and gene-environment interaction analyses. Women wanting to become pregnant should consider optimizing their health and lifestyle.
Graphical abstract
Funder
Nederlandse Organisatie voor Wetenschappelijk Onderzoek Radboud Institute for Health Sciences Nierstichting
Publisher
Springer Science and Business Media LLC
Subject
Nephrology,Pediatrics, Perinatology and Child Health
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