Experimental designs for radiobiological characterization of an accelerator-based BNCT system in preclinical studies

Author:

Masutani MitsukoORCID,Imamichi Shoji,Nakamura Satoshi,Shimada Kenji,Itami Jun,Okamoto Hiroyuki,Ishiai Masamichi,Suzukicell carcimona Minoru,Igaki Hiroshi

Funder

Japan Society for the Promotion of Science London

National Cancer Center Research and Development Fund

Research funds from Cancer Intelligence Care Systems, Inc.

Publisher

Springer Science and Business Media LLC

Reference21 articles.

1. Suzuki M. Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era. Int J Clin Oncol. 2020;25:43–50. https://doi.org/10.1007/s10147-019-01480-4.

2. Kiyanagi Y, Sakurai Y, Kumada H, Tanaka H. Status of accelerator-based BNCT projects worldwide. AIP Conf Proc. 2019;2160:050012. https://doi.org/10.1063/1.5127704.

3. Hirose K, Konno A, Hiratsuka J, et al. Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer (JHN002): An open-label phase II trial. Radiother Oncol. 2021;155:182–7. https://doi.org/10.1016/j.radonc.2020.11.001.

4. Nakamura S, Igaki H, Ito M, Imamichi S, Kashihara T, Okamoto H, Nishioka S, Iijima K, Chiba T, Nakayama H, Takemori M, Abe Y, Kaneda T, Takahashi K, Inaba K, Okuma K, Murakami N, Nakayama Y, Masutani M, Nishio T, Itami J. Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target. Sci Rep. 2021;11:8090. https://doi.org/10.1038/s41598-021-87627-8.

5. Igaki H, Murakami N, Nakamura S, Yamazaki N, Kashihara T, Takahashi A, Namikawa K, Takemori M, Okamoto H, Iijima K, Chiba T, Nakayama H, Takahashi A, Kaneda T, Takahashi K, Inaba K, Okuma K, Nakayama Y, Shimada K, Nakagama H, Itami J. Scalp angiosarcoma treated with linear accelerator-based boron neutron capture therapy: A report of two patients.  Clin Transl Radiat Oncol. 2022;33:128–33. https://doi.org/10.1016/j.ctro.2022.02.006.

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