Abstract
Abstract
Purpose
A meta-analysis was performed to evaluate the prognostic value of neutrophil-lymphocyte ratio (NLR) in patients undergoing potentially curative gastrectomy for cancer (GC).
Methods
Thomson Reuters Web of Science, Ovid MEDLINE(R) and PUBMED databases were searched for relevant articles using search terms neutrophil-lymphocyte ratio (NLR), GC and survival. Articles reporting overall survival (OS), cancer-specific survival and disease-free survival (DFS), in patients undergoing R0 gastrectomy, were studied.
Results
Articles numbering 365 were identified during the preliminary search, and 10 containing 4164 patients were included in the final review. Most patients were > 60 years of age, male (67%) and 2239 (53.8%) had pT3 disease. The number of NLR dichotomization thresholds reported numbered 7, with 2.00 and 3.00 (n = 2) the most common. NLR was associated with poor survival in eight studies with hazard ratios ranging from 1.54 (95% confidence interval (CI) 1.26–1.89) to 2.99 (1.99–4.49). Pooled odds ratio (OR) for OS was 2.31 (1.40–3.83, p = 0.001) and for DFS 2.72 (1.14–6.54, p = 0.020). Four studies presented T-stage data, OR 1.62 (1.33–1.96, p < 0.001).
Conclusion
NLR is an important prognostic indicator associated with both OS and DFS after R0 resection of GC, but the critical level is equivocal.
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,Oncology
Reference31 articles.
1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer [Internet]. 2015 [cited 2017 Dec 11];136:E359–86. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25220842
2. Powell AGMT, Parkinson D, Patel N, Chan D, Christian A, Lewis WG. Prognostic significance of serum inflammatory markers in gastric Cancer. J Gastrointest Surg [Internet]. 2017 [cited 2018 Jan 4]; Available from: https://link.springer.com/content/pdf/10.1007%2Fs11605-017-3597-5.pdf
3. Zhang X, Zhang W, Feng L. Prognostic significance of neutrophil lymphocyte ratio in patients with gastric Cancer: a Meta-analysis. Katoh M, editor. PLoS One [Internet]. 2014 [cited 2017 Dec 11];9:e111906. Available from: https://doi.org/10.1371/journal.pone.0111906
4. Zhang X, Zhang W, Feng L. Prognostic significance of neutrophil lymphocyte ratio in patients with gastric Cancer: a Meta-analysis. Katoh M, editor. PLoS One [Internet]. Public Library of Science; 2014 [cited 2017 Dec 11];9:e111906. Available from: https://doi.org/10.1371/journal.pone.0111906
5. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med [Internet]. 1998 [cited 2017 Dec 11];17:2815–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9921604
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献