Phox2B is a sensitive and reliable marker of paraganglioma—Phox2B immunohistochemistry in diagnosis of neuroendocrine neoplasms

Author:

Manethova Monika,Gerykova Lucie,Faistova Hana,Drugda Jan,Hacova Maria,Hornychova Helena,Ryska Ales,Gabalec Filip,Soukup JiriORCID

Funder

Ministerstvo Zdravotnictví Ceské Republiky

BBMRI-CZ

European Regional Development Fund-Project BBMRI-CZ.: Biobank network

Univerzita Karlova v Praze

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,General Medicine,Pathology and Forensic Medicine

Reference26 articles.

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2. Beumer J, Puschhof J, Bauza-Martinez J, Martinez-Silgado A, Elmentaite R, James KR, Ross A, Hendriks D, Artegiani B, Busslinger GA, Ponsioen B, Andersson-Rolf A, Saftien A, Boot C, Kretzschmar K, Geurts MH, Bar-Ephraim YE, Pleguezuelos-Manzano C, Post Y, Begthel H, van der Linden F, Lopez-Iglesias C, van de Wetering WJ, van der Linden R, Peters PJ, Heck AJR, Goedhart J, Snippert H, Zilbauer M, Teichmann SA, Wu W, Clevers H (2020) High-resolution mRNA and secretome atlas of human enteroendocrine cells. Cell 182:1062–1064. https://doi.org/10.1016/j.cell.2020.08.005

3. Bielle F, Freneaux P, Jeanne-Pasquier C, Maran-Gonzalez A, Rousseau A, Lamant L, Paris R, Pierron G, Nicolas AV, Sastre-Garau X, Delattre O, Bourdeaut F, Peuchmaur M (2012) PHOX2B immunolabeling: a novel tool for the diagnosis of undifferentiated neuroblastomas among childhood small round blue-cell tumors. Am J Surg Pathol 36:1141–1149. https://doi.org/10.1097/PAS.0b013e31825a6895

4. Borges M, Linnoila RI, van de Velde HJ, Chen H, Nelkin BD, Mabry M, Baylin SB, Ball DW (1997) An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 386:852–855. https://doi.org/10.1038/386852a0

5. Drabent P, Bonnard A, Guimiot F, Peuchmaur M, Berrebi D (2020) PHOX2B immunostaining: a simple and helpful tool for the recognition of ganglionic cells and diagnosis of Hirschsprung disease. Am J Surg Pathol 44:1389–1397. https://doi.org/10.1097/PAS.0000000000001528

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