Unusual split green-orange signals in USP6 fluorescence in situ hybridization in a malignant peripheral nerve sheath tumor with a novel NF1-SCIMP fusion: a potential diagnostic pitfall

Author:

Qiu Yan,Jing Wenyi,Zhou Ying,Chen Huijiao,Chen Min,Zhang HongyingORCID

Funder

National Natural Science Foundation of China

Key R&D (Major Science and Technology Project) Project of Sichuan Science and Technology Department

135 Project for Disciplines of Excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,General Medicine,Pathology and Forensic Medicine

Reference22 articles.

1. Patil S, Chamberlain RS (2012) Neoplasms associated with germline and somatic NF1 gene mutations. Oncologist 17:101–116. https://doi.org/10.1634/theoncologist.2010-0181

2. Perry A, Reuss DE, Rodriguez F (2020) Neurofibroma. In: WHO classification of tumours editorial board. Soft Tissue and Bone Tumours. WHO Classification of Tumors, 5th edn. Lyon (France), PA: International Agency for Research on Cancer, pp 232–236

3. Nielsen GP, Chi P ( 2020) Malignant peripheral nerve sheath tumor. In: WHO classification of tumours editorial board. Soft Tissue and Bone Tumours. WHO Classification of Tumors, 5th edn. Lyon (France), PA: International Agency for Research on Cancer, pp 254–257

4. Storlazzi CT, Von Steyern FV, Domanski HA, Mandahl N, Mertens F (2005) Biallelic somatic inactivation of the NF1 gene through chromosomal translocations in a sporadic neurofibroma. Int J Cancer 117:1055–1057. https://doi.org/10.1002/ijc.21248

5. Oliveira AM, Chou MM (2014) USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. Hum Pathol 45:1–11. https://doi.org/10.1016/j.humpath.2013.03.005

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