A Phase I study of acivicin in refractory pediatric solid tumors

Author:

Baruchel Sylvain,Bernstein Mark,Whitehead V. Michael,Devine Susan,Bell Beverly,Dubowy Ronald,Grier Holcombe,Kretschmar Cynthia,Langevin Anne-Marie,Vietti Teresa

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference24 articles.

1. Cooney DA, Jayaram HN, Ryan JA, Bono VH: Inhibition of L-asparagine synthetase by a new amino acid antibiotic with antitumor activity: L-(?5,5S)-?-ami-no-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501). Cancer Chemother Rep 58:793?802, 1974

2. Bennett LL Jr. Glutamine antagonist. In: Sartorelli AC, Johns DG (eds) Handbook of Experimental Pharmacology, Vol. 38, No. 2. Springer-Verlag, New York, 1975, pp. 484?511

3. Reed DJ, Ellis WW, Meck RA: The inhibition of gamma-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells L-(?, 5S)-?-ammo-3-chlo-ro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). Biochem Biophys Res Commun 94:1273?1277, 1980

4. Prajda N: Biochemical mechanism of action of acivicin in rat bone marrow. Proc Am Assoc Cancer Res 27:420, 1986

5. O'Dwyer PJ, Alonso MT, Leyland-Jones B: Acivicin: a new glutamine antagonist in clinical trials. J Clin Oncol 2:1064?1071, 1984

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