Distribution of the liver carcinogen methapyrilene in fischer rats and its interaction with macromolecules

Author:

Lijinsky W.,Muschik G. M.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference4 articles.

1. Andrews AW, Fornwald JA, Lijinsky W (1980) Nitrosation and mutagenicity of some amine drugs. Toxicol Appl Pharmacol 52:237?244

2. Lijinsky W, Reuber MD, Blackwell BN (1980) Liver tumors induced in rats by chronic oral administration of the common antihistaminic methapyrilene hydrochloride. Science 209:817?819

3. Lijinsky W, Ross A (1969) Alkylation of rat liver nucleic acids not related to carcinogenesis by N-nitrosamines. J Natl. Cancer Inst 42:1095?1100

4. Pienta RJ (1980) Evaluation and relevance of the Syrian hamster embryo cell system. In: Williams GM et al. (eds) The predictive value of short-term screening tests in carcinogenicity evaluation. Elsevier/North Holland Biomedical Press, Amsterdam, pp 149?169

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1. Hepatotoxicity;General and Applied Toxicology;2009-12-15

2. Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore;Journal of Pharmacology and Experimental Therapeutics;2008-05-01

3. Preneoplastic Changes During Non-Genotoxic Hepatocarcinogenesis;Liver Carcinogenesis;1994

4. Effects of methrpyrilene measured in mitochondria isolated from naive and methapyrilene-treated rat and mouse hepatocytes;Toxicology and Applied Pharmacology;1992-09

5. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;1991-06

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