CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of irbesartan in healthy Korean subjects

Author:

Choi Chang-Ik,Kim Mi-Jeong,Chung Eun-Kyung,Lee Hye-In,Jang Choon-Gon,Bae Jung-Woo,Lee Seok-Yong

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference27 articles.

1. Marino MR, Vachharajani NN (2001) Drug interactions with irbesartan. Clin Pharmacokinet 40:605–614

2. Perrier L, Bourrié M, Marti E, Tronquet C, Massé D, Berger Y, Magdalou J, Fabre G (1994) In vitro N-glucuronidation of SB 47436 (BMS 186295), a new AT1 nonpeptide angiotensin II receptor antagonist, by rat, monkey and human hepatic microsomal fractions. J Pharmacol Exp Ther 271:91–99

3. Bourrié M, Meunier V, Berger Y, Fabre G (1999) Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes. Drug Metab Dispos 27:288–296

4. Gillis JC, Markham A (1997) Irbesartan. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension. Drugs 54:885–902

5. Marino MR, Langenbacher K, Ford NF, Uderman HD (1998) Pharmacokinetics and pharmacodynamics of irbesartan in healthy subjects. J Clin Pharmacol 38:246–255

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