The reproducibility of bolus allergen challenges; power calculations for clinical trials
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00228-012-1442-z.pdf
Reference10 articles.
1. Gauvreau GM, Evans MY (2007) Allergen inhalation challenge: a human model of asthma exacerbation. Contrib Microbiol 14:21–32
2. Bentley AM, Meng Q, Robinson DS, Hamid Q, Kay AB, Durham SR (1993) Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am J Respir Cell Mol Biol 8:35–42
3. Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M (2007) Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370:1422–1431
4. Singh D, Petavy F, Macdonald AJ, Lazaar AL, O'Connor BJ (2010) The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma. Respir Res 11:26
5. Singh D, Richards D, Knowles RG, Schwartz S, Woodcock A, Langley S et al (2007) Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am J Respir Crit Care Med 176:988–993
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1. Evaluation of New Drugs for Asthma and COPD: Endpoints, Biomarkers and Clinical Trial Design;Handbook of Experimental Pharmacology;2016
2. High- and low-dose allergen challenges in asthmatic patients using inhaled corticosteroids;British Journal of Clinical Pharmacology;2015-02-20
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