Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers

Author:

Joerger M.,Bosch T. M.,Doodeman V. D.,Beijnen J. H.,Smits P. H. M.,Schellens J. H. M.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference12 articles.

1. Momparler RL, Fischer GA (1968) Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside. J Biol Chem 243:4298–4304

2. Song JJ, Walker S, Chen E, Johnson EE, Spychala J, Gribbin T, Mitchell BS (1993) Genomic structure and chromosomal localization of the human deoxycytidine kinase gene. Proc Natl Acad Sci USA 90:431–434

3. Stegmann AP, Honders MW, Bolk MW, Wessels J, Willemze R, Landegent JE (1993) Assignment of the human deoxycytidine kinase (DCK) gene to chromosome 4 band q13.3-q21.1. Genomics 17:528–529

4. Kroep JR, Loves WJ, van der Wilt CL, Alvarez E, Talianidis I, Boven E, Braakhuis BJ, van Groeningen CJ, Pinedo HM, Peters GJ (2002) Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 1:371–376

5. Blackstock AW, Lightfoot H, Case LD, Tepper JE, Mukherji SK, Mitchell BS, Swarts SG, Hess SM (2001) Tumor uptake and elimination of 2′,2′-difluoro-2′-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response. Clin Cancer Res 7:3263–3268

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