Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study-Reference-Cited by-同舟云学术

Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study

Published:2020-01-15 Issue:5 Volume:76 Page:673-683
ISSN:0031-6970
Container-title:European Journal of Clinical Pharmacology
language:en
Short-container-title:Eur J Clin Pharmacol

Author:

Anstensrud Anne Kristine,Molden Espen,Haug Hans Jørgen,Qazi Rehman,Muriq Hysen,Fosshaug Linn E.,Spigset Olav,Øie Erik^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00228-020-02832-0.pdf

Reference27 articles.

1. Freemantle N, Cleland J, Young P, Mason J, Harrison J (1999) Beta blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 318:1730–1737

2. Blake CM, Kharasch ED, Schwab M, Nagele P (2013) A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. Clin Pharmacol Ther 94:394–399

3. Hemeryck A, Lefebvre RA, De Vriendt C, Belpaire FM (2000) Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Pharmacol Ther 67:283–291

4. Berger B, Bachmann F, Duthaler U, Krähenbühl S, Haschke M (2018) Cytochrome P450 enzymes involved in metoprolol metabolism and use of metoprolol as a CYP2D6 phenotyping probe drug. Front Pharmacol 9:774

5. Ingelman-Sundberg M (2005) Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 5:6–13

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