Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients—nonlinear mixed effects modelling approach

Author:

Brzaković Branka,Vučićević Katarina,Kovačević Sandra Vezmar,Miljković Branislava,Prostran Milica,Martinović Žarko,Pokrajac Milena

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference44 articles.

1. Johannessen Landmark C, Patsalos PN (2010) Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Rev Neurother 10:119–140

2. Patsalos PN (2013) Drug interactions with the newer antiepileptic drugs (AEDs)—Part 1: pharmacokinetic and pharmacodynamic interactions between AEDs. Clin Pharmacokinet 52(11):927–966

3. Johannessen Landmark C, Baftiu A, Tysse I, Valso B, Larsson PG et al (2012) Pharmacokinetic variability of four newer antiepileptic drugs, lamotrigine, levetiracetam, oxcarbazepine, and topiramate: a comparison of the impact of age and comedication. Ther Drug Monit 34:440–445

4. GlaxoSmithKline UK (2013) Summary of product characteristics for Lamictal. Available at: http://www.medicines.org.uk/emc/medicine/4228/SPC/Lamictal/#FORM . Accessed 20 Jun 2013

5. Arif H, Svoronos A, Resor SR Jr, Buchsbaum R, Hirsch LJ (2011) The effect of age and comedication on lamotrigine clearance, tolerability, and efficacy. Epilepsia 52:1905–1913

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