Knowledge of developmental pharmacology and modeling approaches should be used to avoid useless trials in children
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00228-009-0655-2
Reference5 articles.
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2. Abdel-Rahman SM, Reed MD, Wells TG, Kearns GL (2007) Considerations in the rational design and conduct of phase I/II pediatric clinical trials: avoiding the problems and pitfalls. Clin Pharmacol Ther 81(4):483–494
3. Merenstein D, Diener-West M, Halbower AC, Krist A, Rubin HR (2006) The trial of infant response to diphenhydramine: the TIRED study–a randomized, controlled, patient-oriented trial. Arch Pediatr Adolesc Med 160(7):707–712
4. Simons KJ, Watson WT, Martin TJ, Chen XY, Simons FE (1990) Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children. J Clin Pharmacol 30(7):665–671
5. Ince I, de Wildt SN, Tibboel D, Danhof M, Knibbe CA (2009) Tailor-made drug treatment for children Creation of an infrastructure for data-sharing and population PK–PD modeling. Drug Discov Today 14(5-6):316–320
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