Is cinnarizine/betahistine combination superior to respective monotherapies in treatment of vertigo? Comment on a randomized triple-blind placebo-controlled trial

Author:

Amini Kiumarth,Taghizadeh-Ghehi MaryamORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference5 articles.

1. Asadi P, Zia Ziabari SM, Majdi A, Vatanparast K, Naseri Alavi SA (2019) Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. Eur J Clin Pharmacol 75(11):1513–1519. https://doi.org/10.1007/s00228-019-02741-x

2. Vanderkam P, Blanchard C, Naudet F, Pouchain D, Vaillant Roussel H, Perault-Pochat MC, Jaafari N, Boussageon R (2019) Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials. Eur J Clin Pharmacol 75(5):603–607. https://doi.org/10.1007/s00228-018-02617-6

3. Murdin L, Hussain K, Schilder AGM (2016) Betahistine for symptoms of vertigo. Cochrane Database Syst Rev 6. https://doi.org/10.1002/14651858.CD010696.pub2

4. Scholtz AW, Hahn A, Stefflova B, Medzhidieva D, Ryazantsev SV, Paschinin A, Kunelskaya N, Schumacher K, Weisshaar G (2019) Efficacy and safety of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg vs betahistine dihydrochloride 16 mg in patients with peripheral vestibular vertigo: a prospective, multinational, multicenter, double-blind, randomized, non-inferiority clinical trial. Clinical drug investigation 39(11):1045–1056. https://doi.org/10.1007/s40261-019-00858-6

5. Cirek Z, Schwarz M, Baumann W, Novotny M (2005) Efficacy and tolerability of a fixed combination of cinnarizine and dimenhydrinate versus betahistine in the treatment of otogenic vertigo : a double-blind, randomised clinical study. Clinical drug investigation 25(6):377–389. https://doi.org/10.2165/00044011-200525060-00003

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