Effects of ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of abemaciclib

Author:

Maeda AkimitsuORCID,Ando HitoshiORCID,Irie KeiORCID,Hashimoto Naoya,Morishige Jun-ichi,Fukushima Shoji,Okada Akira,Ebi HiromichiORCID,Matsuzaki Masahide,Iwata Hiroji,Sawaki Masataka

Funder

Aichi Cancer Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference33 articles.

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2. Sledge GW Jr, Toi M, Neven P, Sohn J, Inoue K, Pivot X, Burdaeva O, Okera M, Masuda N, Kaufman PA, Koh H, Grischke EM, Frenzel M, Lin Y, Barriga S, Smith IC, Bourayou N, Llombart-Cussac A (2017) MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2-advanced breast cancer who had progressed while receiving endocrine therapy. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 35(25):2875–2884. https://doi.org/10.1200/jco.2017.73.7585

3. Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, Park IH, Tredan O, Chen SC, Manso L, Freedman OC, Garnica Jaliffe G, Forrester T, Frenzel M, Barriga S, Smith IC, Bourayou N, Di Leo A (2017) MONARCH 3: abemaciclib as initial therapy for advanced breast cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 35(32):3638–3646. https://doi.org/10.1200/jco.2017.75.6155

4. Sledge GW Jr, Toi M, Neven P, Sohn J, Inoue K, Pivot X, Burdaeva O, Okera M, Masuda N, Kaufman PA, Koh H, Grischke EM, Conte P, Lu Y, Barriga S, Hurt K, Frenzel M, Johnston S, Llombart-Cussac A (2020) The effect of abemaciclib plus fulvestrant on overall survival in hormone receptor-positive, ERBB2-negative breast cancer that progressed on endocrine therapy-MONARCH 2: a randomized clinical trial. JAMA Oncol 6(1):116–124. https://doi.org/10.1001/jamaoncol.2019.4782

5. Fujiwara Y, Tamura K, Kondo S, Tanabe Y, Iwasa S, Shimomura A, Kitano S, Ogasawara K, Turner PK, Mori J, Asou H, Chan EM, Yamamoto N (2016) Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer. Cancer Chemother Pharmacol 78(2):281–288. https://doi.org/10.1007/s00280-016-3085-8

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