Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model

Author:

Mikhail Andrew S.,Levy Elliot B.,Krishnasamy Venkatesh P.,Woods David L.,Esparza-Trujillo Juan A.,Bakhutashvili Ivane,Banovac Filip,Wakim Paul G.,Negussie Ayele H.,Tang Yiqing,Henman Alexander,Willis Sean L.,Karanian John W.,Pritchard William F.,Lewis Andrew L.,Wood Bradford J.

Funder

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,Radiology, Nuclear Medicine and imaging

Reference30 articles.

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2. Xu G, Zhang W, Ma MK, McLeod HL. Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res Off J Am Assoc Cancer Res. 2002;8(8):2605–11.

3. Guichard S, Terret C, Hennebelle I, Lochon I, Chevreau P, Fretigny E, et al. CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues. Br J Cancer. 1999;80(3–4):364–70.

4. Forster RE, Small SA, Tang Y, Heaysman CL, Lloyd AW, Macfarlane W, et al. Comparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancer. J Mater Sci Mater Med. 2010;21(9):2683–90.

5. Lewis AL, Hall B. Toward a better understanding of the mechanism of action for intra-arterial delivery of irinotecan from DC Bead (DEBIRI). Future Oncol. 2019;15(17):2053–68.

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