In silico high throughput screening and in vitro validation of a novel Raf/Mek dual inhibitor against colorectal carcinoma
Author:
Funder
King Khalid University
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Plant Science,Genetics,Molecular Biology,Animal Science and Zoology,Biochemistry,Ecology, Evolution, Behavior and Systematics
Link
https://link.springer.com/content/pdf/10.1007/s11756-022-01197-2.pdf
Reference33 articles.
1. Al Shahrani M, Abohassan M, Alshahrani MY, Hakami AR, Rajagopalan P (2021) High-throughput virtual screening and preclinical analysis identifies CB-1, a novel potent dual B-Raf/c-Raf inhibitor, effective against wild and mutant variants of B-Raf expression in colorectal carcinoma. J Comput Aided Mol Des 35(12):1165–1176. https://doi.org/10.1007/s10822-021-00426-1
2. Al-Kuraya KS (2009) KRAS and TP53 mutations in colorectal carcinoma. Saudi J Gastroenterol 15(4):217–219. https://doi.org/10.4103/1319-3767.56087
3. Anderson MW, Reynolds SH, You M, Maronpot RM (1992) Role of proto-oncogene activation in carcinogenesis. Environ Health Perspect 98:13–24. https://doi.org/10.1289/ehp.929813
4. Armaghany T, Wilson JD, Chu Q, Mills G (2012) Genetic alterations in colorectal cancer. Gastrointest Cancer Res 5(1):19–27
5. Asati V, Mahapatra DK, Bharti SK (2016) PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives. Eur J Med Chem 109:314–341. https://doi.org/10.1016/j.ejmech.2016.01.012
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