Investigation of spirooxindole-pyrrolidine derivatives as acetylcholinesterase inhibitors using molecular docking/dynamics simulations, bioisosteric replacement, MEP, and ADME/Tox properties
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Plant Science,Genetics,Molecular Biology,Animal Science and Zoology,Biochemistry,Ecology, Evolution, Behavior and Systematics
Link
https://link.springer.com/content/pdf/10.1007/s11756-023-01528-x.pdf
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2. Ali MA, Ismail R, Choon TS, Yoon YK, Wei AC, Pandian S, Kumar RS, Osman H, Manogaran E (2010) Substituted spiro [2.3′] oxindolespiro [3.2 ″]-5, 6-dimethoxy-indane-1 ″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase. Bioorg Med Chem Lett 20:7064–7066. https://doi.org/10.1016/j.bmcl.2010.09.108
3. Allain H, Bentue-Ferrer D, Akwa Y (2008) Disease-modifying drugs and Parkinson’s disease. Prog Neurobiol 84:25–39. https://doi.org/10.1016/j.pneurobio.2007.10.003
4. Ambure P, Kar S, Roy K (2014) Pharmacophore mapping-based virtual screening followed by molecular docking studies in search of potential acetylcholinesterase inhibitors as anti-Alzheimer's agents. Biosystems 116:10–20. https://doi.org/10.1016/j.biosystems.2013.12.002
5. Arun Y, Bhaskar G, Balachandran C, Ignacimuthu S, Perumal PT (2013) Facile one-pot synthesis of novel dispirooxindole-pyrrolidine derivatives and their antimicrobial and anticancer activity against A549 human lung adenocarcinoma cancer cell line. Bioorg Med Chem Lett 23:1839–1845. https://doi.org/10.1016/j.bmcl.2013.01.023
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