The effect of formulation variables on protein stability and integrity of a model IgG4 monoclonal antibody and translation to formulation of a model ScFv-Reference-Cited by-同舟云学术

The effect of formulation variables on protein stability and integrity of a model IgG4 monoclonal antibody and translation to formulation of a model ScFv

Published:2017-09-23 Issue:1 Volume:40 Page:33-46
ISSN:0141-5492
Container-title:Biotechnology Letters
language:en
Short-container-title:Biotechnol Lett

Author:

Gourbatsi Evdoxia,Povey Jane F.,Smales C. Mark^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Biotechnology,Bioengineering,Applied Microbiology and Biotechnology

Link

http://link.springer.com/article/10.1007/s10529-017-2443-x/fulltext.html

Reference31 articles.

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3. Breen ED, Curley JG, Overcashier DE, Hsu CC, Shire SJ (2001) Effect of moisture on the stability of a lyophilized humanized monoclonal antibody formulation. Pharm Res 18:1345–1353

4. Carpenter JF, Kendrick BS, Chang BS, Manning MC, Randolph TW (1999) Inhibition of stress-induced aggregation of protein therapeutics. Methods Enzymol 309:236–255

5. Chen B, Bautista R, Yu K, Zapata GA, Mulkerrin MG, Chamow SM (2003) Influence of histidine on the stability and physical properties of a fully human antibody in aqueous and solid forms. Pharm Res 20:1952–1960

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