Expandase-like activity mediated cell-free conversion of ampicillin to cephalexin by Streptomyces sp. DRS I

Author:

Thakur D.,Roy M. K.,Bora T. C.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Biotechnology,Bioengineering,Applied Microbiology and Biotechnology

Reference18 articles.

1. Adrio JL, Cho H, Piret JM, Demain AL (1999) Inactivation of deacetoxycephalosporin C synthase in extracts of Streptomyces clavuligerus during bioconversion of penicillin G to deacetoxycephalosporin G. Enzyme Microb Technol 25:497–501

2. Cho H, Adrio JL, Luengo JM, Wolfe S, Ocran S, Hintermann G, Piret JM, Demain AL (1998) Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1. Proc Natl Acad Sci USA 95:544–548

3. Cortes J, Martin JF, Castro JM, Laiz L, Liras P (1987) Purification and characterization of 2-oxoglutarate linked ATP independent deacetoxycephalosporin C synthase of S. lactamdurans. J Gen Microbiol 133:3165–3174

4. Dotzlaf JE, Yeh WK (1987) Copurification and characterization of eacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium. J Bacteriol 169:1611–1618

5. Fernández MJ, Adrio JL, Piret JM, Wolfe S, Ro S, Demain AL (1999) Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1. Appl Microbiol Biotechnol 52:484–488

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1. Biosynthesis of active pharmaceuticals: β-lactam biosynthesis in filamentous fungi;Biotechnology and Genetic Engineering Reviews;2010-01

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