Highly enantioselective bioreduction of N-methyl-3-oxo-3-(thiophen-2-yl) propanamide for the production of (S)-duloxetine

Author:

Tang Chuan-Gen,Lin Hui,Zhang Chao,Liu Zhang-Qin,Yang Tao,Wu Zhong-Liu

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Biotechnology,Bioengineering,Applied Microbiology and Biotechnology

Reference20 articles.

1. Allen CFH, Humphlett WJ (1963) Benzoylacetanilide. Org Synth 4:80–83

2. Barnett JA, Payne RW, Yarrow D (2000) Yeasts: characteristics and identification. Cambridge University Press, Cambridge, UK

3. Breuer M (2008) Method for production of optically active (1S)-3-chloro-1-(2-thienyl)-propan-1-ol. US Patent 0319208-A1

4. Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH, Mitchell S, Robertson DW, Thompson DC, Wallace L, Wong DT (2003) Duloxetine (CymbaltaTM), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett 13:4477–4480

5. Deeter J, Frazier J, Staten G, Staszak M, Weigel L (1990) Asymmetric synthesis and absolute stereochemistry of LY248686. Tetrahedron Lett 31:7101–7104

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