Cartilage Restoration in the Adolescent Knee: a Systematic Review-Reference-Cited by-同舟云学术

Cartilage Restoration in the Adolescent Knee: a Systematic Review

Published:2019-11-26 Issue:4 Volume:12 Page:486-496
ISSN:1935-9748
Container-title:Current Reviews in Musculoskeletal Medicine
language:en
Short-container-title:Curr Rev Musculoskelet Med

Author:

Coughlin Ryan P.,Gupta Arnav,Sogbein Olawale A.,Shanmugaraj Ajaykumar,Kurz Adrian Z.,Simunovic Nicole,Yen Yi-Meng,Ayeni Olufemi R.

Publisher

Springer Science and Business Media LLC

Subject

Orthopedics and Sports Medicine

Link

http://link.springer.com/content/pdf/10.1007/s12178-019-09595-x.pdf

Reference27 articles.

1. • DiBartola AC, Wright BM, Magnussen RA, Flanigan DC. Clinical outcomes after autologous chondrocyte implantation in adolescents’ knees: a systematic review. Arthrosc J Arthrosc Relat Surg. 2016;32(9):1905–16. https://doi.org/10.1016/j.arthro.2016.03.007Purpose: To perform a systematic review of the use of autologous chondrocyte implantation (ACI) in the adolescent knee. Specific aims: (1) quantify clinical outcomes of ACI in adolescent knees, (2) identify lesion and patient factors that correlate with clinical outcome, and (3) determine the incidence of complications of ACI in adolescents. Methods: PubMed, MEDLINE, SCOPUS, CINAHL, and Cochrane Collaboration Library databases were searched systematically. Outcome scores recorded included the International Knee Documentation Committee score, the International Cartilage Repair Society score, the Knee Injury and Osteoarthritis Outcome score, the visual analog scale, the Bentley Functional Rating score, the Modified Cincinnati Rating System, Tegner activity Lysholm scores, and return athletics. Outcome scores were compared among studies based on the proportion of adolescents achieving specific outcome quartiles at a minimum of 1-year follow-up. The methodological quality of studies was evaluated by Coleman methodology scores (CMSs). Results: Five studies reported on 115 subjects who underwent ACI with periosteal cover (ACI-P; 95, 83%), ACI with type I/type III collagen cover (ACI-C; 6, 5%), or matrix-induced ACI (MACI; 14, 12%). The mean patient age was 16.2 years (range, 11 years to 21 years). All studies were case series. Follow-up ranged from 12 to 74 months (mean, 52.3 months). The mean defect size was 5.3 cm 2(range, 0.96 cm 2to 14 cm 2). All studies reported improvement in clinical outcomes scores. Graft hypertrophy was the most common complication (7.0%). The mean preoperative clinical outcome percentage (based on the percentage of outcome scale used) was 37% (standard deviation (SD), 18.9%), and the mean postoperative clinical outcome percentage was 72.7% (SD, 16.9%). The overall percentage increase in clinical outcome scores was 35.7% (SD, 14.2%). The mean CMS was 47.8 (SD, 8.3). Conclusions: Cartilage repair in adolescent knees using ACI provides success across different clinical outcomes measures. The only patient- or lesion-specific factor that influenced clinical outcome was the shorter duration of preoperative symptoms. Level of evidence: level IV, a systemic review of level I–IV studies.

2. Perera J, Gikas P, Bentley G. The present state of treatments for articular cartilage defects in the knee. Ann R Coll Surg Engl. 2012;94(6):381–7. https://doi.org/10.1308/003588412X13171221592573.

3. Habelt S, Hasler CC, Steinbrück K, Majewski M. Sport injuries in adolescents. Orthop Rev. 2011;3(2):18. https://doi.org/10.4081/or.2011.e18.

4. Kaszkin-Bettag M. Is autologous chondrocyte implantation (ACI) an adequate treatment option for repair of cartilage defects in paediatric patients? Drug Discov Today. 2013;18(15–16):740–7. https://doi.org/10.1016/j.drudis.2013.04.007.

5. Siparsky P, Bailey J, Dale K, Klement M, Taylor D. Open reduction internal fixation of isolated chondral fragments without osseous attachment in the knee. Orthop J Sports Med. 2017;5:232596711769628. https://doi.org/10.1177/2325967117696281.

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