Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity-Reference-Cited by-同舟云学术

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Published:2010-08-29 Issue:5 Volume:128 Page:529-538
ISSN:0340-6717
Container-title:Human Genetics
language:en
Short-container-title:Hum Genet

Author:

van Kuilenburg André B. P.,Meijer Judith,Mul Adri N. P. M.,Meinsma Rutger,Schmid Veronika,Dobritzsch Doreen,Hennekam Raoul C. M.,Mannens Marcel M. A. M.,Kiechle Marion,Etienne-Grimaldi Marie-Christine,Klümpen Heinz-Josef,Maring Jan Gerard,Derleyn Veerle A.,Maartense Ed,Milano Gérard,Vijzelaar Raymon,Gross Eva

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics

Link

http://link.springer.com/content/pdf/10.1007/s00439-010-0879-3

Reference36 articles.

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3. Cho HJ, Park YS, Kang WK, Kim JW, Lee SY (2007) Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity. Ther Drug Monit 29:190–196

4. Collie-Duguid ESR, Etienne MC, Milano GA, McLeod HL (2000) Known variant DPYD alleles do not explain DPD deficiency in cancer patients. Pharmacogenetics 10:217–223

5. Dobritzsch D, Schneider G, Schnackerz KD, Lindqvist Y (2001) Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil. EMBO J 20:650–660

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