A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi-Reference-Cited by-同舟云学术

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

Published:2020-02-24 Issue:2 Volume:10 Page:101-104
ISSN:2192-2195
Container-title:Natural Products and Bioprospecting
language:en
Short-container-title:Nat. Prod. Bioprospect.

Author:

Wu Xiu-Rong,Shen Yi,Cui Shu-Jun,Luo Xiao-Lei,Xiao Chao-Jiang^ORCID,Jiang Bei^ORCID

Abstract

Abstract One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day. Graphic Abstract

Funder

National Natural Science Foundation of China

the Innovation Team Project of Dali University for the Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry

Link

http://link.springer.com/content/pdf/10.1007/s13659-020-00234-4.pdf

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