Abstract
AbstractAn asymmetric total synthesis of (+)-21-epi-eburnamonine has been achieved. Key features of the synthesis include a visible-light photocatalytic intra-/intramolecular radical cascade reaction to assemble the tetracyclic ABCD ring system, and a highly diastereoselective Johnson-Claisen rearrangement to establish the C20 all-carbon quaternary stereocenter.
Graphic Abstract
Funder
National Natural Science Foundation of China
National Major Science and Technology Projects of China
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry
Reference73 articles.
1. J.E. Saxton, in The Eburnamine-Vincamine Group, ed. by A. Weiss-berger, E. Taylor. Indoles part IV: The Monoterpene Indole Alkaloids, (Wiley, New York, 1983), p. 439–465
2. Atta-ur-Rahman, M. Sultana, Heterocycles 22, 841–858 (1984)
3. M. Lounasmaa, A. Tolvanen, in G. A. Cordell. vol 42. ed. by T. Alkaloids (Academic Press, New York, 1992), pp. 1–116
4. J.E. Saxton, Nat. Prod. Rep. 11, 493–531 (1994)
5. J.E. Saxton, Nat. Prod. Rep. 13, 327–363 (1996)
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献