Abstract
AbstractThree new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC50 values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.
Graphical Abstract
Funder
National Natural Science Foundation of China
Science and Technology Program of Guangzhou, China
Southern Marine Science and Engineering Guangdong Laboratory
Open Program of Shenzhen Bay Laboratory
Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
Guangdong Basic and Applied Basic Research Foundation, China
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry