Abstract
AbstractSteroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga®), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited.
Funder
National Natural Science Foundation of China
Yunnan Science and Technology Project
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry
Reference363 articles.
1. Schultz HB, Meola TR, Thomas N, Prestidge CA. Oral formulation strategies to improve the bioavailability and mitigate the food effect of abiraterone acetate. Int J Pharm. 2020;577: 119069.
2. Bailly C, Zhang J. A new horizon for the steroidal alkaloid cyclovirobuxine D (huangyangning) and analogues: anticancer activities and mechanism of action. J Tradit Chin Med Sci. 2020;7:337–44.
3. Evans R, Cham BE, Daunter B. Curaderm. Med J Aust. 1989;150:350.
4. Keeler RF, Binns W. Teratogenic compounds of Veratrum californicum (Durand). I. Preparation and characterization of fractions and alkaloids for biologic testing. Can J Biochem. 1966;44:819–28.
5. Cooper MK, Porter JA, Young KE, Beachy PA. Teratagon-mediated inhibition of target tissue response to Shh signaling. Science. 1998;280:1603–1603.
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献